Aktivitas Antioksidan Masker Gel Peel-off Ekstrak Rimpang Temu Ireng (Curcuma aeruginosa Roxb.)
Abstract
Temu ireng (Curcuma aeruginosa Roxb.) mengandung senyawa flavonoid yang memiliki daya antioksidan dan dapat dijadikan sediaan masker gel peel-off. Tujuan penelitian ini yaitu untuk mengetahui aktivitas antioksidan masker gel peel-off ekstrak rimpang temu ireng menggunakan metode DPPH (1,1-diphenyl-2-picrylhydrazyl). Ekstrak rimpang temu ireng diperoleh dengan cara maserasi menggunakan etanol 70%. Ekstrak rimpang temu ireng dimanfaatkan sebagai bahan aktif dalam pembuatan masker gel peel-off. Metode DPPH digunakan untuk menentukan aktivitas antioksidan berdasarkan nilai IC50. Nilai IC50 ekstrak rimpang temu ireng sebesar 746,75μg/mL, nilai IC50 masker gel peel-off ekstrak rimpang temu ireng sebesar 5.569,90μg/mL, dan nilai IC50 vitamin C sebesar 24,65μg/mL. Dari hasil penelitian disimpulkan bahwa masker gel peel-off ekstrak rimpang temu ireng memiliki aktivitas antioksidan berdaya sangat lemah dengan IC50 5.569,90μg/mL.
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Akarchariya, N., Sirilun, S., Julsrigival, J., & Chansakaowa, S. (2017). Chemical profiling and antimicrobial activity of essential oil from Curcuma aeruginosa Roxb., Curcuma glans K. Larsen & J. Mood and Curcuma cf. xanthorrhiza Roxb. collected in Thailand. Asian Pacific Journal of Tropical Biomedicine, 7(10), 881–885. https://doi.org/10.1016/j.apjtb.2017.09.009
Arif, M., & Serpil, D. (2023). Recent Advances in Triazoles as Tyrosinase Inhibitors. European Journal of Medicinal Chemistry, 259(115665). https://doi.org/https://doi.org/10.1016/j.ejmech.2023.115655
Astri, S., & Anis, Y. C. (2016). Formulasi Masker Gel Peel Off Untuk Perawatan Kulit Wajah. Farmaka, 14(3), 17–26.
Chen, Z., Zhao, Y., Zhang, M., Yang, X., Yue, P., Tang, D., & Wei, X. (2020). Structural characterization and antioxidant activity of a new polysaccharide from Bletilla striata fibrous roots. Carbohydrate Polymers, 227(September 2019), 115362. https://doi.org/10.1016/j.carbpol.2019.115362
Dewi, I. P., Dachriyanus, Aldi, Y., Ismail, N. H., Hefni, D., Susanti, M., Syafri, S., & Wahyuni, F. S. (2024). Curcuma Aeruginosa Roxb. Extract Inhibits the Production of Proinflammatory Cytokines on Raw 264.7 Macrophages. International Journal of Applied Pharmaceutics, 16(1), 41–44. https://doi.org/10.22159/ijap.2024.v16s1.08
Dewi, I. P., Verawaty, & Taslim, T. (2023). Aktivitas Imunomodulator Esktrak Etanol Daun Sambiloto (Andrographis paniculata Ness) Pada Mencit Putih. Jurnal Kesehatan Perintis, 10(1), 1–6.
Fendri, S. T. J., Irwandi, I., Fidausa, A. A., & Ferilda, S. (2022). Ekstrak Etanol Buah Rotan (Daemonorops sp) terhadap Pertumbuhan Bakteri Staphylococcus aureus dan Escherichia coli. Jurnal Kesehatan Perintis, 9(2), 68–75.
Garg, A., Aggarwal, D., Garg, S., & Singla, A. K. (2002). Spreading of semisolid formulations: An update. Pharmaceutical Technology North America, 26(9), 84–105.
Hidayana, V. (2015). Uji Sitotoksik Ekstrak Etanol Rimpang Temu Hitam (Curcuma aeruginosa Roxb.) Terhadap Larva Udang (Artemiasalina leach). Jurnal Kesehatan Perintis, 2(2), 59–60.
Jinhong, H., Yao, W., Chang, S., You, L., Zhao, M., Cheung, P. C.-K., & Hileuskaya, K. (2022). Structural characterization and anti-photoaging activity of a polysaccharide from Sargassum fusiforme. Food Research International, 157(111267). https://doi.org/https://doi.org/10.1016/j.foodres.2022.111267
Lan, C. C. E., Hung, Y. T., Fang, A. H., & Ching-Shuang, W. (2019). Effects of irradiance on UVA-induced skin aging. Journal of Dermatological Science, 94(1), 220–228. https://doi.org/10.1016/j.jdermsci.2019.03.005
Mamay, M., Wardani, D., & Hakim, F. (2022). Aktivitas Antioksidan Total pada Ekstrak Etanol Daun Bambu Surat (Gigantochloa pseudoarundinaceae). Jurnal Kesehatan Perintis (Perintis’s Health Journal), 9(1), 47–52. https://doi.org/10.33653/jkp.v9i1.797
Nurcholis, W., Priosoeryanto, B. P., Purwakusumah, E. D., Katayama, T., & Suzuki, T. (2012). Antioxidant, Cytotoxic Activities and Total Phenolic Content of Four Indonesian Medicinal Plants. Jurnal Kimia VALENSI, 2(4). https://doi.org/10.15408/jkv.v2i4.267
Ojo, A. B., & Adanlawo, I. G. (2024). Antioxidant, antidiabetic, and anti-inflammatory activities of flavonoid-rich fractions of Solanum anguivi Lam. fruit: In vitro and ex vivo studies. Heliyon, 10(11), e31895. https://doi.org/10.1016/j.heliyon.2024.e31895
Oktavia, T., Suci, P. R., Ikhda, C., & Hamidah, N. (2021). Formulasi Dan Uji Mutu Fisik Ekstrak Rimpang Temu Ireng ( Curcuma aeruginosa Roxb .) Sebagai Masker Gel Peel Off Pencerah Wajah. Seminar Nasional Pendidikan Biologi Dan Saintek (SNPBS), VI, 337–344.
Sukandiarsyah, F., Purwaningsih, I., & Ratnawaty, G. J. (2023). Aktivitas Antioksidan Ekstrak Rimpang Temu Ireng (Curcuma aeruginosa Roxb.) Metode DPPH. Jurnal Mandala Pharmacon Indonesia, 9(1), 62–70. https://doi.org/10.35311/jmpi.v9i1.299
Sulfianti, A., Ningsih, S., & Agustini, K. (2019). Chemoprevention Effect of Curcuma Aeruginosa in Dmba-Induced Cytokines Production. International Research Journal Of Pharmacy, 10(3), 54–59. https://doi.org/10.7897/2230-8407.100378
Susiloningrum, D., & Mugita Sari, D. E. (2021). Uji Aktivitas Antioksidan Dan Penetapan Kadar Flavonoid Total Ekstrak Temu Mangga ( Curcuma Mangga Valeton & Zijp ) Dengan Variasi Konsentrasi Pelarut. Cendekia Journal of Pharmacy, 5(2), 117–127. https://doi.org/10.31596/cjp.v5i2.148
Wardaniati, I., & Yanti, R. (2018). Uji Aktivitas Antioksidan Ekstrak Etanol Propolis Lebah Trigona ( Trigona itama ). Journal of Pharmacy and Science, 2(1), 14–21.
Warnida, H., Oktaviani, R., & Sukawaty, Y. (2016). Formulasi Masker Gel Peel Off Ekstrak Etanol Umbi Bawang Dayak(Eleutherine bulbosa (Mill.) Urb.). Media Sains, 9(2), 167–173.
Wu, H., Zhao, W., Zhou, J., Xie, X., Zhong, X., Liu, Y., & Shi, L. (2024). Extraction, analysis of antioxidant activities and structural characteristics of flavonoids in fruits of Diospyros lotus L. Lwt, 201(May), 116248. https://doi.org/10.1016/j.lwt.2024.116248
Yumita, A., Dwitiyanti, D., & Ermawati, P. (2022). Aktivitas Antikonvulsan Ekstrak Rimpang Temu Ireng (Curcuma aeruginosa Roxb.) Pada Tikus Putih Jantan Menggunakan Elektrokonvulsiometer. Jurnal Ilmiah Farmasi Farmasyifa, 5(1), 41–51. https://doi.org/10.29313/jiff.v5i1.8829
Zhan, X., Jia, L., Niu, Y., Qi, H., Chen, X., Zhang, Q., Zhang, J., Wang, Y., Dong, L., & Wang, C. (2014). Targeted depletion of tumour-associated macrophages by an alendronate-glucomannan conjugate for cancer immunotherapy. Biomaterials, 35(38), 10046–10057. https://doi.org/10.1016/j.biomaterials.2014.09.007
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